Summary

The Jorgez Laboratory in the Department of Urology at Baylor College of Medicine is seeking a highly motivated Staff Scientist to join an NIH-funded research program investigating the molecular and developmental mechanisms underlying testicular dysfunction and infertility in a Wnt4 conditional knockout (Wnt4-cKO) mouse model. This position offers the opportunity to work at the interface of developmental biology, reproductive endocrinology, and cutting-edge spatial and 3D imaging technologies, within a collaborative, well-resourced research environment in the Texas Medical Center.

Job Duties

• Design and execute experiments using mouse models, including breeding colony management and genotyping

• Perform advanced 3D and spatial imaging (confocal, LSFM, Xenium spatial transcriptomics) and associated computational image analysis

• Conduct cellular and molecular assays including, immunohistochemistry, proteomic profiling, and tissue-derived cell culture-based functional studies

• Analyze, interpret, and present complex multimodal datasets integrating imaging, transcriptomic, and proteomic data

• Prepare manuscripts for peer-reviewed publication and contribute to grant progress reports and future funding applications

• Maintain reagents and supply for experiments

• Teach techniques, procedures, and experimental design to other members of the lab

• Communicate research results in group meetings, national or international conferences

• Plan, direct, and conduct research experiments

• Develop research techniques and perform applications required for specific research projects

• Perform other job-related duties as assigned

Minimum Qualifications

• Doctoral Degree. Experience may not be substituted in lieu of degree.
• Three years of post doctoral research experience.

Department Specific Criteria

• Experience with advanced 3D imaging modalities (light sheet fluorescence microscopy, confocal microscopy) and/or spatial transcriptomics platforms (e.g., Xenium, Visium)
• Background in male reproductive biology, testicular development, or endocrinology

Preferred Qualifications

• Experience working on the Wnt/Bcatenin signaling pathway
• Experience with bioinformatic analysis of transcriptomic or proteomic datasets
• Prior experience with animal surgical techniques (e.g., orchidopexy models)