Summary
We are seeking an experienced and highly motivated Staff Scientist to lead research using mouse models of aging, neurodegenerative disease, and adult neurogenesis. The Staff Scientist will play a central role in experimental design, execution, and integration across longitudinal in vivo studies, ensuring rigor, reproducibility, and continuity in complex animal-based research programs. The position is ideal for a scientist who values deep biological insight, hands-on experimentation, and collaborative, translational neuroscience.
Job Duties
- Design, execute, and oversee experiments using mouse models of aging, neurodegeneration, and neural plasticity, including longitudinal and interventional studies
- Perform and supervise in vivo and ex vivo techniques, including:
- Behavioral phenotyping
- BrdU/EdU-based neurogenesis assays
- Immunohistochemistry, confocal imaging, and quantitative morphometry
- Molecular and cellular analyses of brain tissue
- Establish, optimize, and maintain mouse colonies, including aging cohorts and disease models
- Develop and standardize protocols to ensure experimental rigor, reproducibility, and regulatory compliance
- Integrate molecular, cellular, and behavioral data across experimental platforms
- Mentor and train students, technicians, and postdoctoral fellows in animal models and experimental neuroscience
- Contribute substantially to manuscript preparation, grant applications, and progress reports
- Collaborate closely with computational scientists, clinicians, and translational research teams
- Perform other job related duties as assigned
Minimum Qualifications
- Doctoral Degree. Experience may not be substituted in lieu of degree.
- Three years of post doctoral research experience.
Preferred Qualifications
- PhD (or MD/PhD) in neuroscience, neurobiology, biology, or a related field
- Extensive hands-on experience with mouse models of aging and/or neurodegenerative disease
- Strong background in adult neurogenesis, brain plasticity, or neural stem cell biology
- Demonstrated expertise in experimental design, quantitative analysis, and scientific writing
- Proven ability to work independently while contributing to team-based, interdisciplinary science
- Six or more years of experience working on neurogenesis and neurodegenerative models
- Experience with age-related neurodegenerative disorders (e.g., Alzheimer’s disease)
- Familiarity with metabolic, inflammatory, or epigenetic mechanisms of brain aging
- Experience coordinating complex or long-term in vivo studies
- Record of authorship on peer-reviewed publications and participation in funded research programs
Work Authorization Requirement:
This position is not eligible for visa sponsorship. Candidates must be legally authorized to work in the United States at the time of application and throughout the duration of employment.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.