Title:  Research Associate

Division:  Biochemistry
Schedule:  Monday - Friday 8:00 a.m. - 5:00 p.m.
Work Location:  Texas Medical Center, Houston, TX
Salary Range:  $60,000 - $70,000
FLSA Status:  Exempt
Requisition ID:  1851
Summary

The Therapeutic Innovation Center is seeking talented cell and molecular biologists to work in an interdisciplinary team environment on early therapeutic and drug discovery projects. As our key focus is on diseases of gene regulation, with an emphasis on cancer, this position will involve cancer cell line engineering and characterizing the consequences of target perturbation using a variety of phenotypic assays. In particular, this work will focus on understanding the function of RNA helicases in normal and disease states and the consequences of RNA helicase perturbation on cell fitness. Candidates will be expected to plan, execute and analyze assigned experiments with minimal supervision and to be able to troubleshoot as needed.

Job Purpose

The key focus of the department is on diseases of gene regulation, with an emphasis on cancer, this position will involve engineering cancer cell lines to perturb gene of interest function and characterizing the consequences of this perturbation using a variety of assays to measure cell growth/death and other downstream phenotypes. In particular, this work will focus on understanding the function of RNA helicases in normal and disease states and the consequences of RNA helicase perturbation on cell fitness.

 

Job Responsibilities
  • Plans and executes experimental protocols to perturb (RNAi, CRISPR, over-expression, etc) gene of interest function in a variety of cell lines.
  • Plans, executes and analyzes experimental protocols to characterize the phenotypic and molecular consequences of gene of interest perturbation.
  • Generates constructs required for assigned experiments via molecular cloning techniques including standard restriction, Gateway and Gibson technologies.
  • Clearly documents and communicates (oral and written) experimental results and progress.
  • Annotates and maintains collaborative protocol repositories for all lab members.
  • Works collaboratively with chemical and molecular biologists to engineer and characterize mammalian cell lines that can be used to study the mechanism of gene regulation in cancer.
  • Works independently and effectively in a highly dynamic, multi-disciplinary environment.
  • Cleans and maintains laboratory equipment, supplies and work areas.
  • Periodic exposure to unpleasant conditions but the work is still viewed as relatively comfortable in a laboratory environment.
  • Frequently handles/works with biohazards or risks for potential job-related injury, such as those found in an ordinary laboratory environment.
Minimum Qualifications

Education:

Required: Master's degree in Basic Science or a related field.  Experience in lieu of degree will not be accepted.

Experience:

Required: Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.

 


 

 

 

 

 

Preferred Qualifications

Master's degree in cell and/or molecular biology or related field of science and at least three years of relevant experience. Experience in lieu of degree will not be accepted.

FLSA Status

Exempt

 

 

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 1851

CA; CH