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Title:  Research Assistant II

Division:  Pediatrics
Schedule:  Monday - Friday, 8:00 a.m. - 5:00 p.m.
Work Location:  Texas Medical Center, Houston, TX
Salary Range:  $40,785 - $49,506
FLSA Status:  Exempt
Requisition ID:  3201
Summary

The lab requires a Research Assistant II, capable of performing research work of a complex nature that requires establishing test methods and procedures and planning, completing, and occasionally supervising limited research projects in accordance with general plans approved by the supervisor. The PI has expertise in the biology of hematologic malignancies with a current focus on the genomic and epigenetics of leukemogenesis and chemoresistance. The lab work includes the development and characterization of murine models of leukemogenesis including modeling of acute myeloid leukemias with mutations of NPM1, FLT3, DNMT3A, TET2, cohesin complex members and KRAS. The lab also has expertise in the interrogation of the genetic and epigenetic program of hematopoietic cells utilizing deep sequencing methodologies such as RNAseq, ChIPseq, and whole genome bisulfite sequencing. The lab also has expertise in CRISPR-Cas9 genome editing technology. The lab applies this broad skill set to the translational study of human leukemia. PI's lab's recent work includes a translational study defining the histone modifier, DOT1L as a novel epigenetic target for the treatment of AML with mutations of the gene DNMT3A and a mapping of the mutational landscape of mixed phenotype acute leukemia. The lab is also using CRISPR-Cas9 engineered human B lymphoblastic leukemia cells to study the impact of loss of the lymphoid transcription factor, IKZF1, on leukemogenesis and resistance to therapy.

Job Duties
  • Plans, directs, and conducts research experiments.
  • Evaluates and analyzes data.
  • Conducts literature searches and summarizes information in an appropriate format for a particular study.
  • Documents results of experiments and reports to principal investigators.
  • Prepares figures for presentations and publications.
  • Writes manuscripts under the supervision of the principal investigator.
  • Trains and orients less experienced research staff.
  • Defines problems and possible solutions.
  • Oversees the maintenance of lab equipment and environment.
  • May assign activities to less experienced research staff.
Minimum Qualifications
  • Education Required: Bachelor's degree in a Basic Science or a related field. 
  • Experience Required: Three years of relevant experience.
  • Certification/Licenses/Registration: None Required.
Preferred Qualifications
  • Preferred: Master's degree in a related field.
  • Requires precision in preparing materials and recording data.
  • Prefer experience working with mice and tissue culture.
  • Prefer experience with next generation sequencing technologies.
  • Prefer experience with CRISPR-Cas9.
Other
  • Frequently handles/works with biohazards or risks for potential job-related injury, such as those found in an ordinary laboratory or clinic environment. environment.

 

 

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 3201

CA; CH