Title:  Research Assistant II

Division:  Biochemistry
Schedule:  Monday - Friday 8:00 a.m. - 5:00 p.m.
Work Location:  Texas Medical Center, Houston, TX
Salary Range:  $40,785 - $60,000
FLSA Status:  Exempt
Requisition ID:  1752
Summary

The Therapeutic Innovation Center is embarking on a programmatic effort to advance drug discovery for RNA helicases in cancer.

Job Purpose

We are seeking talented scientists with background knowledge in gene regulation and expertise in genetically engineered mouse models (generation and maintenance) and mammalian cell culture to enable translation of basic science findings toward drug discovery

Job Responsibilities
  • Plans and executes animal model based experiments to enable phenotypic studies of gene of interest knockout/perturbation.
  • Properly documents and maintains animal colony including initiating proper breeding schemes to achieve desired number of each genotype and genotyping all animals in a timely fashion.
  • Maintains animal protocol and stays up to date on training required for work with animals.
  • Maintains mammalian cancer cell line stocks and supports chemical and cell biologists by assisting with experiments where needed.
  • Clearly documents and communicates (oral and written) experimental results and progress.
  • Annotates and maintains collaborative protocol repositories for all lab members.
  • Cleans and maintains laboratory equipment, supplies and work areas.
  • Periodic exposure to unpleasant conditions but the work is still viewed as relatively comfortable in a laboratory environment.
  • Frequently handles/works with biohazards or risks for potential job-related injury, such as those found in an ordinary laboratory environment.
Minimum Qualifications

Education:

  • Required: Bachelor's degree in a Basic Science or related field.

Experience:

  • Required: Three years of relevant experience.

Certification/Licenses/
Registration:

  • None required.

 

Preferred Qualifications

Bachelor’s degree in cell and/or molecular biology or related field of science and at least three years of relevant experience. Master’s degree in preferred.

Other

Preferred requirements and skills:

  • Expertise in genetically engineered mouse models and animal care including breeding schemes, genotyping, and colony maintenance.
  • Expertise in animal handling and general surgery techniques including IP injection, oral gavage, and subcutaneous transplantation of human xenografts.
  • Experience in mammalian cell culture including lentiviral/retroviral production, genetic perturbation techniques including RNAi and CRISPR/CAS9 technologies, and stable cell line generation/maintenance.
  • Experience with the following techniques: transfection/electroporation, flow cytometry, immunohistochemistry/immunofluorescence, DNA/RNA/protein extraction, western blot, PCR
  • Competency in one or more key areas including: genetically engineered mouse models, mammalian cell culture and gene regulation.
FLSA Status

Exempt

 

 

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 1752

CA; CH