Title:  Research Assistant II

Division:  Biochemistry
Schedule:  Monday - Friday 8:00 a.m. - 5:00 p.m
Work Location:  Texas Medical Center, Houston, TX
Salary Range:  $40,785 - $60,000
FLSA Status:  Exempt
Requisition ID:  1751
Summary

The Therapeutic Innovation Center is embarking on a programmatic effort to advance drug discovery for RNA helicases in cancer. We are seeking talented molecular biologists to work in an interdisciplinary team environment on understanding how gene regulation is altered in disease to enable translation of basic science findings toward drug discovery

Job Purpose

The Therapeutic Innovation Center is seeking talented molecular biologists to work in an interdisciplinary team environment on early cancer therapeutic and drug discovery projects. As our key focus is on diseases of gene regulation, with an emphasis on cancer, this position will involve working closely with chemical and cell biologists to understand the function of RNA helicases in normal and disease states and the consequences of RNA helicase perturbation. Candidates will be expected to plan, execute and analyze assigned experiments with minimal supervision and to be able to troubleshoot as needed

Job Responsibilities
  • Generates constructs required for assigned experiments via molecular cloning techniques including standard restriction, Gateway and Gibson technologies.
  • Plans, executes and analyzes data from research experiments.
  • Clearly documents and communicates (oral and written) experimental results and progress.
  • Annotates and maintains collaborative protocol repositories for all lab members.
  • Works independently and effectively in a highly dynamic, multi-disciplinary environment.
  • Cleans and maintains laboratory equipment, supplies and work areas.
  • Periodic exposure to unpleasant conditions but the work is still viewed as relatively comfortable in a laboratory environment.
  • Frequently handles/works with biohazards or risks for potential job-related injury, such as those found in an ordinary laboratory environment.
Minimum Qualifications

Education:

  • Required: Bachelor's degree in a Basic Science or related field.

Experience:

  • Required: Three years of relevant experience.

Certification/Licenses/
Registration:

  • None required.
Preferred Qualifications
  • Bachelor’s degree in cell and/or molecular biology or related field of science and at least three years of relevant experience preferred.
  • Master’s degree in cell and/or molecular biology or related field of science preferred.
Other

Preferred knowledge, skills, and abilities:​​​​​​​

  • Expertise in standard molecular techniques, including Western blotting, molecular cloning (restriction digest, Gateway, etc), DNA, RNA and protein isolation, PCR, cDNA library construction, qPCR and co-immunoprecipitation.
  • Experience with next-generation sequencing (NGS) library preparation of various types, including ChIP-seq, RNAseq, CLIP, ATAC-seq, etc.
  • Experience with mammalian cell culture, including lentiviral/retroviral production, genetic perturbation techniques including RNAi and CRISPR/CAS9 technologies, and stable cell line generation/maintenance, is preferred.
  • Competency in one or more key areas including: molecular biology, mammalian cell culture and gene regulation.

 

 

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 1751

CA; CH