Summary

We are seeking a postdoctoral associate in a laboratory at the Jan and Dan Duncan NRI focused on the underlying genetics and molecular mechanisms of genetic neurological disorders. Candidate will work alongside current postdoctoral associates working on Alzheimer's Disease, Parkinson's Disease, and MeCP2 projects.

Job Duties

• Investigates the mechanisms underlying cerebrovascular abnormalities in Rett syndrome, focusing on the hippocampus. Building on findings that VEGF inhibition reduces seizures without normalizing hypervascularization, the candidate 
• Tests the hypothesis that these pathways contribute to disease pathology.
• Conducts in vivo experiments using pharmacological and genetic tools to modulate candidate pathways, including ICV infusions and viral-mediated gene transfer. Advanced histological, molecular, and transcriptomic techniques will be employed to assess vascular remodeling and its impact on neural function.
• Plans, directs and conducts specialized and advanced research experiments as above.
• Evaluates and analyzes data, establishes new research protocols and procedures.
• Summarizes research findings and publishes results in research journals. 
• Attends departmental seminars, weekly lab meetings/journal club meetings. When assigned, candidate will present research findings at lab meeting and discussed assigned journals at journal club. 

Minimum Qualifications

• Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• Requires molecular biology approaches, systems neuroscience approaches, biochemistry, shRNA injections in mice and tissue analyses.