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Title:  Postdoctoral Fellow - Genomics and Bioinformatics

Division:  Ophthalmology
Schedule:  Monday - Friday, 8:00 am - 5:00 pm
Work Location:  Houston, TX
Salary Range:  Hiring up to $56,608
FLSA Status:  Exempt
Requisition ID:  9351

Summary

An open position for a Postdoctoral Fellow in human molecular genetics/genomics field is available in the laboratory of Rinki Ratnapriya, Ph.D. at the Department of Ophthalmology, Baylor College of Medicine, Houston, TX.

The successful applicant will work on functional characterization of AMD-GWAS signals to understand the molecular basis of observed genetic associations. The position will focus heavily on analysis of high-throughput bulk and single-cell multi-omic data (ATAC-seq and RNA-seq) in ocular tissues. The applicant should have strong molecular biology skills and some experience in programming (Python and R). The candidate must demonstrate scientific productivity, rigor and creativity with a strong publication record in peer-reviewed scientific journals.

The Ratnapriya lab focuses on harnessing the power of genomic technologies to address translational and clinical bioinformatic challenges pertaining to retinal and macular degenerative diseases. We are working towards understanding the role of variable gene expression driven by non-coding cis-regulatory sequence variation in context of Age-related macular degeneration (AMD), which is the leading cause of blindness in elderly. Genome-wide association studies (GWAS) have established a major role for variable gene expression as the basis for AMD disease risk. However, the interpretation of GWAS findings remains a major challenge as the majority of disease-associated variants reside outside the protein-coding regions and we have limited understanding of how associated variants translate into disease pathogenesis. We generate multiple high-throughput functional genomics data sets on the genome, epigenome, and transcriptome in disease-relevant tissues/cells and use of computational approaches to integrate and analyze this data to identify the molecular components and the structure of the regulatory apparatus underlying gene expression variation.

 

For more information please visit: https://www.bcm.edu/people-search/rinki-ratnapriya-29180

Job Duties

  • The candidate will be responsible for planning, conducting and analyzing research projects.
  • Dissociates human/model organisms tissue samples and prepares them for next-generation sequencing (NGS) compatible experiments.
  • Designs, implements, and operates bioinformatics pipelines using existing analytical tools for NGS applications.
  • Applies intellectual curiosity and passion for applying data science to biomedical problems.
  • Summarizes, visualizes, and communicates research and analyses findings to principal investigator and for research publications in scientific journals.
  • Responsible for laboratory operations and supervising research staff.

Minimum Qualifications

  • Ph.D. in Basic Science, Health Science, or a related field.

Preferred Qualifications

  • Ph.D. in human genetics, genetics, genomics, bioinformatics or other related field.

Other

  • To apply for the position, qualified candidates should submit a one-page cover letter stating reasons for their scientific interest in the lab, career goals, a curriculum vitae including technical skills, and the names and contact information of three references.

 

 

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 9351

CA; PD