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Title:  Postdoctoral Associate

Division:  Pediatrics
Schedule:  Monday - Friday, 8:00 a.m. - 5:00 p.m.
Work Location:  Texas Medical Center, Houston, TX
Salary Range:  $52,704 - $53,640
FLSA Status:  Exempt
Requisition ID:  5193
Summary

The Heczey Lab is seeking a Postdoctoral Associate to study differentiation, exhaustion and the proliferative capacity of effector lymphocytes and optimize non-viral vector systems for genetic engineering to ultimately deliver an effective cell therapy to cancer patients.  The laboratory has a strong translational and early phase clinical arm and focuses on developing the next generation of engineered lymphocyte based therapies to the clinic.  The primary focus of the Postdoctoral Associate will be to work in the pre-clinical setting using state-of-the-art equipment in the exceptional environment of the shared Translational Research Lab of the Center for Cell and Gene Therapy of Baylor College of Medicine and the Cancer Center of Texas Children's Hospital.

 

Job Duties
  • Cell culture maintenance
  • gRNA design and assembly
  • plasmid and viral particle production
  • flow cytometry
  • ELISA
  • Western Blot
  • work in the small animal facility
  • Transcriptomic and deep phenotypic characterization of next generation CAR T cells, Gene knock out and knock in experiments, in vitro and in vivo expansion, persistence and antitumor response measurements
  • Plan, direct and conduct specialized and advanced research experiments
  • Evaluate and analyze data
  • May establish new research protocols and procedures
  • Summarize research findings and publish results in research journals
  • May be responsible for laboratory operations
  • May supervise research staff
Minimum Qualifications
  • MD or Ph.D in Basic Science, Health Science, or a related field.
Preferred Qualifications
  • PhD relevant to immunology focused on lymphocyte biology, genetic engineering, CRISPR-Cas9 based gene modification.
  • The applicant must be well experienced in aseptic techniques related to T cell culture, multiparametric flow cytometry, ELISA.
  • Candidates with significant knowledge of gene knock in strategies with CRISPR/Cas9 and animal handling experience will be prioritized.

 

 

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 5193

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