Summary

The Di Stefano Lab at Baylor College of Medicine seeks a talented and motivated Postdoctoral Associate to join the dynamic research team investigating post-transcriptional and epigenetic mechanisms that control cell fate, stem cell plasticity, and cancer progression. The lab operates within an interdisciplinary, collaborative network at Baylor College of Medicine and the Texas Medical Center, providing access to world-class facilities, core resources, and diverse scientific expertise.

Research Focus
The lab employs cutting-edge genomic technologies that includes ribosome profiling, CLIP-seq, single-cell multiomics, CUT&Tag, and long-read sequencing to dissect gene regulatory mechanisms at single-cell and systems levels. Current projects explore how RNA-binding proteins and RNA modifications govern stem cell fate and oncogenesis.
Recent Publications
• Pessina et al., bioRxiv (2025) – RNA condensates in developmental cell fate transitions
• Kodali et al., Nature Reviews Immunology (2025) – biomolecular condensates in immune cell fate
• Kodali et al., Nature Cell Biology (2024) – biomolecular condensates in leukemia
• Levin Ferreyra et al., EMBO Reports (2025) – Regulation of pluripotency
• Di Stefano et al., Cell Stem Cell (2019); Nature Cell Biology (2016); Nature (2014) – chromatin and RNA regulation of cell identity

Training Environment 

The lab champions scientific creativity, methodological rigor, and comprehensive mentorship. Postdoctoral Associate receive dedicated support in developing independent research projects and building scientific leadership skills. Our trainees have a strong track record of publishing in premier journals and advancing to successful academic and industry careers.

Baylor College of Medicine offers an outstanding biomedical research environment within the Texas Medical Center, providing access to world-class facilities, cutting-edge core resources, competitive NIH-level stipends, and comprehensive benefits.

Interested candidates should submit a cover letter describing research interests and career goals, curriculum vitae, and contact information for three references.

Baylor College of Medicine typically follows similar to the NIH stipulated stipend guidelines for Postdoctoral Associates.

Job Duties

• Leads independent research projects in RNA biology, stem cell biology, or cancer models.
• Designs and executes experiments using high-throughput sequencing and molecular biology techniques.
• Collaborates actively with lab members, bioinformaticians, and clinical teams.
• Communicates research through manuscript preparation, grant writing, and conference presentations.
• Mentors trainees and contributes to a collaborative, supportive lab environment.
• Performs other job-related duties as assigned.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• PhD in Molecular Biology, Cell Biology, Genetics, Biochemistry, or related field.
• Strong foundation in RNA biology, gene regulation, or stem cell research.
• Hands-on experience with genomics methods (RNA-seq, RIP/CLIP, ATAC-seq, scRNA-seq).
• Experience with translational profiling, splicing analysis, or RNA editing.
• Background in pluripotency, 3D embryo models, hematopoietic or cancer model systems
• Computational biology skills.
• Collaborative mindset with ability to work independently.
• Demonstrated productivity through publications or preprints.
• Excellent communication and organizational abilities.