Summary

Brain tumor research laboratory is currently seeking an outstanding young scientist to join the group as a Postdoctoral Associate focused on mechanisms regulating stem and progenitor cell function in medulloblastoma using cutting edge cell biology, molecular biology and bioinformatics techniques. The Postdoctoral Associate will be recent PhD graduates with high levels of energy and curiosity, and who are interested in making fundamental discoveries in understanding the molecular biology and developmental origins of pediatric brain tumors. 

The Ogilvie lab has made significant contributions to the underlying cellular and molecular mechanisms regulating medulloblastoma stem cell fate decisions (https://www.bcm.edu/people-search/tamra-ogilvie-132696). This includes identification of medulloblastoma cells of origin (Nature, 2022), central regulators of medulloblastoma self-renewal (ie. Nature, 2022; Nature Communications, 2020, Molecular Oncology, 2018) and potential diagnostic biomarkers for different molecular subgroups (i.e., Cancer Research, 2018). Postodoctoral Associate will work in a highly collaborative environment in Dr. Ogilvie's lab and as part of the newly established Pediatric Neuro-Oncology Research Program at Baylor College of Medicine. 

Baylor College of Medicine typically follows similar to the NIH stipulated stipend guidelines for Postdoctoral Associates.

Job Duties

• Integrates results from cell culture and molecular experiments to further generate hypotheses that will be tested functionally using a variety of assays both in vitro and in vivo. 
• Develops and optimizes protocols for the lab and implements new technologies for specific research projects. Train others in the lab on these new technologies. 
• Analyzes and interprets data (proteomics, ChIP-seq and RNAseq) in light of tumour evolution, with the aim of understanding the underlying dynamics of pediatric brain tumour growth and heterogeneity. 
• Performs extensive confocal imaging and analyses.
• Performs extensive flow cytometry studies and analyses.
• Works extensively on manuscript/grant drafts, figures and cover letters for submission to journals. 
• Mentors junior lab members.
• Represents occasionally the lab at national and international scientific meetings. 
• Performs other job-related duties as assigned.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• PhD with previous training in stem cell biology, molecular biology, confocal imaging, and flow cytometry.
• Post doctoral Associate must have Ph.D. conferral date within the last 3 years.
• Experience with stem cell biology (ie. cell culture, in vivo transplantation assays) and molecular biology,  large-scale genomic data is desired.
• Experience with flow cytometry and confocal microscopy is desired.
• Prior first author publications is desired.
• Be self-motivated, well-organized, highly independent, and willing to train new students.
• Excellent communication, written and interpersonal skills are mandatory.