Summary

The Di Stefano Lab at Baylor College of Medicine seeks a talented and motivated Postdoctoral Fellow to join our dynamic research team investigating post-transcriptional and epigenetic mechanisms that control cell fate, stem cell plasticity, and cancer progression. Research Focus We employ cutting-edge genomic technologies—including ribosome profiling, CLIP-seq, single-cell multiomics, CUT&Tag, and long-read sequencing—to dissect gene regulatory mechanisms at single-cell and systems levels. Current projects explore how RNA-binding proteins and RNA modifications govern stem cell fate and oncogenesis.

Recent Publications

• Pessina et al., bioRxiv (2025) – RNA condensates in developmental cell fate transitions
• Kodali et al., Nature Reviews Immunology (2025) – biomolecular condensates in immune cell fate
• Kodali et al., Nature Cell Biology (2024) – biomolecular condensates in leukemia
• Levin Ferreyra et al., EMBO Reports (2025) – Regulation of pluripotency
• Di Stefano et al., Cell Stem Cell (2019); Nature Cell Biology (2016); Nature (2014) – chromatin and RNA regulation of cell identity 

Our lab champions scientific creativity, methodological rigor, and comprehensive mentorship. Postdocs receive dedicated support in developing independent research projects and building scientific leadership skills. Our trainees have a strong track record of publishing in premier journals and advancing to successful academic and industry careers. Baylor College of Medicine provides an exceptional biomedical research environment with competitive salaries and comprehensive benefits. Application Process Please submit a cover letter, CV, and contact information for 2–3 references to Dr. Bruno Di Stefano at bruno.distefano@bcm.edu. Informal inquiries are encouraged. Applications will be reviewed continuously until the position is filled. 

Job Duties

Our lab operates within an interdisciplinary, collaborative network at Baylor College of Medicine and the Texas Medical Center, providing access to world-class facilities, core resources, and diverse scientific expertise.

• Leads independent research projects in RNA biology, stem cell biology, or cancer models.
• Designs and executes experiments using high-throughput sequencing and molecular biology techniques.
• Collaborates actively with lab members, bioinformaticians, and clinical teams.
• Communicates research through manuscript preparation, grant writing, and conference presentations.
• Mentors trainees and contribute to a collaborative, supportive lab environment.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• Strong foundation in RNA biology, gene regulation, or stem cell research
• Hands-on experience with genomics methods (RNA-seq, RIP/CLIP, ATAC-seq, scRNA-seq)
• Demonstrated productivity through publications or preprints
• Excellent communication and organizational abilities
• Collaborative mindset with ability to work independently Preferred Qualifications 
• Experience with translational profiling, splicing analysis, or RNA editing
• Background in pluripotency, 3D embryo models, hematopoietic or cancer model systems
• Computational biology skills
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• What We Offer