Title:  Postdoctoral Associate- Proteomics

Division:  Pharmacology and Chemical Biology
Schedule:  Monday - Friday; 8:00 a.m. - 5:00 p.m.
Work Location:  Houston, TX
Salary Range:  Per NIH Guidelines
FLSA Status:  Exempt
Requisition ID:  18135


A Postdoctoral Associate position in proteomics is available in the laboratory of Dr. Nicolas Young in the Verna & Marrs McLean Department of Biochemistry & Molecular Pharmacology at Baylor College of Medicine. 


You will join an established NIH funded laboratory that is focused on developing innovative proteomics approaches and using these to new methods to address basic science and human health relevant questions. We use proteomics to identify and quantitate post-translational modifications (PTMs) and single molecular combinations of PTMs (proteoforms). In this effort we make extensive use of cutting-edge approaches such as nanoflow liquid chromatography, quantitative top-down proteomics, electron transfer dissociation, and novel in house data analysis algorithms. We apply these innovations to a variety of basic biology questions revolving around the regulation and dysregulation of the human genome. We use these approaches to address multiple diseases, including leukemia, aging, and neurodegeneration.


As a postdoctoral associate in a dynamic research program, you will have unparalleled opportunities for scientific and career advancement. You will work as part of a cross-disciplinary team where each member will be able to enhance their previous experience with new skills and expertise. You will be required to learn new skills and develop the ability to execute all aspects of deeply multi-disciplinary projects. You will also work as a team, contributing your primary expertise and benefiting from others, to address cutting edge, high impact problems. 


Baylor College of Medicine is a top Medical and Biosciences Graduate School with a long history of innovation and leadership in the biomedical sciences. Baylor College of Medicine is located in the center of the world's largest life science complex in the heart of the third most populous city in America. 
Direct inquiries of well-qualified candidates are encouraged by directly contacting:



Additional information on the Young lab is available online:

A formal online application is required at: http://jobs.bcm.edu

Job Duties

  • Focuses on data analysis and bioinformatics of quantitative top-down proteomics approaches in chromatin and epigenetics as well as quantitative bottom up proteomics of enriched lysosomes in mouse models of aging and Alzheimer’s disease. 
  • Involves understanding how multiple post-translational modifications on proteins function in concert, on single molecules, to regulate the genome.  This position is funded by a program project focused on Alzheimer’s Disease and Aging. 
  • Leads research projects to better understand epigenetic mechanisms of the brain and the regulation and function of the lysosome. This includes in developmental, aging, and neurodegeneration contexts. 
  • Develops and applies mass spectrometry and data analysis approaches to multiple related experimental platforms and assists graduate students and other postdoctoral associates with data analysis and bioinformatics. 
  • Leads projects, designs experiments, and collaborates with other scientists to accomplish research goals.
  • Evaluates and analyzes top-down and bottom-up mass spectrometry data and develops computational approaches to analyze top-down data.
  • Interprets proteoform meaning, writes papers and contributes to grant writing.

Minimum Qualifications

  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience required.

Preferred Qualifications

  • Ph.D. from an accredited institution.
  • Expertise in proteomics.
  • Good publication record.
  • Efficient time management skills, and a strong work ethic.
  • Excellent scientific writing skills and be able to take a leading role in the writing and publication of diverse scientific articles addressing advances in methodology and functional and mechanistic inquiry into fundamental biology.
  • Most importantly you must be passionate about solving unanswered questions by digging deeper into specific biochemical events using proteomics.



Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.