Title:  Postdoctoral Associate- Cellular Heterogeneity and Circuit Organization of Brains

Division:  Neuroscience
Schedule:  Monday - Friday, 8:00 a.m. - 5:00 p.m.
Work Location:  Houston, TX
Salary Range:  Per NIH Guidelines
FLSA Status:  Exempt
Requisition ID:  16776

Summary

The Jiang laboratory in the Departments of Neuroscience at Baylor College of Medicine is seeking applicants for postdoc associate positions. The specific goal of the postdoc fellows for these positions is to use a multi-disciplinary approach, including single-cell RNA sequencing, Patch-seq, multi-patch clamp recording, machine learning, and complicated genetic tools to understand cellular heterogeneity and circuit organization of healthy and diseased brains. The fellows will use rodent and primate models, including surgically resected human tissue, to understand brain cell types with the molecular, spatial, and morpho-electric annotations, and how genetic lesions (related to epilepsy and autism) give rise to culprit cell types that contribute to the core symptoms of the diseases.
 
You can learn more about our research at https://www.bcm.edu/research/labs-and-centers/faculty-labs/xiaolong-jiang-lab and more specific information for current projects from recent publications in our labs:
 
Jiang X., Shen S., Cadwell C.R., Berens P., Sinz F., Ecker A.S., Tolias A.S. (2015). Principles of Connectivity among Morphologically Defined Cell Types in Adult Neocortex. Science. Vol. 350 no. 6264 DOI: 10.1126
 
Cadwell CR, Palasantza A, Jiang X, Berens P, Deng Q, Yilmaz M, Reimer J, Shen S, Bethge M, Tolias KF, Sandberg R & Tolias AS (2016). Morphological, electrophysiological, and transcriptomic profiling of single neurons using Patch-seq. Nature Biotechnology, 34(2), 199-203. doi: 10.1038/nbt.3445. Epub 2015 Dec 21.
 
Scala F, Kobak D, Shan S, Bernaerts Y, Laturnus S, Cadwell CR, Hartmanis H, Castro J, Tan ZH, Sandberg S, Berens P, Jiang X*, Tolias AT*. Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas. Nature Communication. volume 10, Article number: 4174 (2019) *co-corresponding authors
 
McKinney A, Hu M, Hoskins A, Mohammadyar A, Naeem N, Jing J, Patel S, Sheth RB. Jiang X. Cellular composition and circuit organization of the locus coeruleus in adult mice. Elife. 2023 Feb 3;12:e80100.
 
Shen S, Scala F, Reimer J, Fu J, Fahey P, Sinz. F, Jiang X#, Tolias AS. Distinct organization of two cortico-cortical feedback pathways. Nature Communication, 2022 Oct 27;13(1):6389. #*co-corresponding authors 
 
 

Job Duties

  • Uses single-nucleus RNA-sequencing, Patch-seq, multi-patching electrophysiology, and other molecular techniques on brain tissue to decipher and define cellular constituents of cortical circuits with molecular, morpho-electric, spatial, and functional annotations in the primate and rodent brain.
  • Probes and defines the cellular constituents of brain circuits associated with epilepsy and autism.
  • Performs rigorous and well-controlled experiments as well as data analysis.
  • Summarizes research findings, publish results in research journals, and presentation of research results at professional conferences.
     

Minimum Qualifications

  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience required.

Preferred Qualifications

  • Experience with patch-clamp electrophysiology.
  • Excellent written/oral communication and organizational skills are required, and work effectively in a team environment.
  • Experience with single-cell RNA-seq, bioinformatics analysis, and molecular techniques.
     

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.