Title:  Postdoctoral Associate- CAR T-cell studies

Division:  Center for Gene Therapy
Schedule:  Based on workload
Work Location:  Houston, TX
Salary Range:  Hiring up to $53,760
FLSA Status:  Exempt
Requisition ID:  8067


A postdoctoral position is open at The Center for Cell and Gene Therapy to conduct correlative/mechanistic studies in first-in-man Phase I clinical trials to understand mechanisms regulating leukemia and lymphoma resistance to CAR T-cell therapy and factors regulating the activity of engineered CAR T-cells in patients. Applicants are sought to design and perform correlative CAR T-cell studies on samples obtained in ongoing Phase I clinical trials of CAR T-cells as well as the GMP-manufactured CAR T-cell products. Clinical activity of CAR T-cells will be replicated in relevant PDX models.

Job Purpose

Postdoctoral Associates are trainees working in an apprenticeship mode in preparation for a career as a scientific professional.

Job Duties

  • Designs and performs cell-based assays for high-throughput analyses of CAR T-cells (e.g., multimodal flow cytometry, RNA-seq).
  • Analyzes multi-dimensional data in collaboration with the bioinformatics group.
  • Establishes patient-derived xenograft models of leukemia and lymphoma for preclinical testing of next-generation products.
  • Performs pilot experiments to test specific hypotheses in preclinical CAR-T cell development to inform the next generation of CAR T-cell therapies.
  • Assists with writing reports and manuscripts and present at scientific meetings.
  • Maintains a timely log of experimental notes.

Minimum Qualifications

  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience.

Preferred Qualifications

  • Ph.D in Immunology or Cell Biology strongly desired.
  • Experience with immunology, mouse models, and high-throughput single-cell assays is a plus.
  • Experience in cell biology and flow cytometry is strongly preferred.
  • Experience with transcriptomics / high-throughout assays is a bonus.





Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.