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Title:  Postdoctoral Associate

Division:  Pathology
Schedule:  Monday-Friday; 8:00am-5:00pm
Work Location:  Texas Medical Center, Houston, TX
Salary Range:  Hiring up to $62,000
FLSA Status:  Exempt
Requisition ID:  2620
Job Purpose

The Tom Cooper lab is looking for a highly motivated individual to investigate the networks regulating alternative splicing during normal heart and skeletal muscle development, the functions of the resulting protein isoform transitions and the pathogenic mechanisms in diseases in which these networks are disrupted. 

 

We use predominately mammalian in vivo experimental systems. One area of investigation is our longstanding interest in understanding the pathogenic mechanisms of, and developing therapeutic approaches for, the microsatellite expansion disorder, myotonic dystrophy (DM1) in which disrupted alternative splicing is a predominant pathogenic mechanism. 

 

A second area of investigation is the function of conserved alternative splicing events during heart and skeletal muscle postnatal development. We identified fetal-to-adult protein isoform transitions that are required for normal function in adult mice using CRISPR-mediated removal of alterantive exons to force expression of only the fetal isoforms. Alternative splicing affected in DM1 is of particular interest. 

Job Duties
  • Plans, directs and conducts specialized and advanced research experiments.
  • Evaluates and analyzes data.
  • May establish new research protocols and procedures.
  • Summarizes research findings and publish results in research journals.
  • May be responsible for laboratory operations.
  • May supervise research staff.
Minimum Qualifications
  • Education: Ph.D in Basic Science, Health Science, or a related field.
  • Experience: None required.
Other

Link to more information about the lab. (https://www.bcm.edu/research/labs/tom-cooper/?PMID=14453) 

 

 

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 2620

PD